A variety of genetic and acquired factors can disrupt the small intestine brush border, which may result in low activity of brush border enzymes. SIBB-Zymes™ supplies a blend of enzymes normally found in the small intestinal brush border that are critical for the final steps of carbohydrate and protein digestion. Disaccharide enzymes (lactase, maltase, and sucrase) are supplied together with glucoamylase to assist optimal cleaving of sugars and carbohydrates that if left undigested may affect absorption and microbial fermentation, contributing to a shift in the balance of yeast and bacteria.

SIBB-Zymes™ includes an active enzyme blend of peptidase and protease with dipeptidyl peptidase IV (DPP-IV) activity. Peptidase and protease enzymes help break down plant and animal proteins, including casein (milk/dairy products), gluten (wheat, rye, oats, barley, and other grains), and soy. Peptidase enzymes that express DPP-IV activity are especially effective in breaking down proline-rich exorphin (opiate-acting) peptides derived from incompletely digested casein, gluten, and soy that may influence central nervous system function in some individuals. SIBB-Zymes™ can help break down dietary disaccharides and oligosaccharides, including lactose.